Spherical crystallization: A technique use to reform solubility and flow property of active pharmaceutical ingredients

From Form to Function: Crystallization of Active Pharmaceutical Ingredients

S ince the introduction of aspirin in 1899, and more particularly since the advent of antibiotic ‘‘wonder drugs’’ in the 1940s, society has come to rely on the widespread availability of therapeutic drugs at reasonable prices. It was a tremendous challenge to bring penicillin to market and could not have been done without the simultaneous development of both product and process under the inspir...

New Trends in the Co-crystallization of Active Pharmaceutical Ingredients

Pharmaceutical materials science being a fundamental branch that continuously provides important insights, theories, and technologies to formulation sciences. The recent advances in this area have brought the possibility to produce pharmaceutical materials by design. In particular, the formation of co-crystals, i.e. crystalline molecular complexes of twoor more neutral molecules, represents a p...

Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates.

The increasing prevalence of poorly soluble drugs in development provides notable risk of new products demonstrating low and erratic bioavailability with consequences for safety and efficacy, particularly for drugs delivered by the oral route of administration. Although numerous strategies exist for enhancing the bioavailability of drugs with low aqueous solubility, the success of these approac...

Flow reactor networks for integrated synthesis of active pharmaceutical ingredients

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Recrystallization of Active Pharmaceutical Ingredients